Chronopharmacology of antitumor drugs.

Chronopharmacology and Mechanism of Antitumor Effect of Erlotinib in Lewis Tumor-Bearing Mice

The epidermal growth factor receptor (EGFR), a ubiquitously expressed receptor tyrosine kinase, is recognized as a key mediator of tumorigenesis in many human epithelial tumors. Erlotinib is tyrosine kinase inhibitor approved by FDA for use in oncology. It inhibits the intracellular phosphorylation of tyrosine kinase associated with the EGFR to restrain the development of the tumor. To investig...

Annual Review of Chronopharmacology

The f r a c t i o n a l d i s t r i b u t i o n o f l y m p h o c y t e subsets was d e t e r m i n e d i n t h r e e m a l e s u b j e c t s . I t s c o n t r i b u t i o n t o t h e c i r c a d i a n v a r i a t i o n i n t h e exp r ess i on o f ß2~adrenoceptor s i t e s on pe r iphera l m o n o n u c l e a r l e u c o c y t e s ( M N L ) was c a l c u l a t e d t o be 92 .7 -107 .3 % o f t ...

Chronopharmacology of melatonin in mice to maximize the antitumor effect and minimize the rhythm disturbance effect.

The influence of dosing time on the antitumor effect and the rhythm disturbance effect of melatonin (MLT) was investigated in ICR male mice under a light/dark (12:12) cycle. In tumor-bearing mice, the antitumor effect of MLT (1 mg/kg intraperitoneal) was most effective in the dark phase; and the rhythm disturbance effect of MLT on the locomotor activity was more serious in the light phase than ...

Annual Review of Chronopharmacology

Evaluation of Chronosensitivity and Chronopharmacology of some centrally acting potential drugs in albino wistar rats

Many of the drugs leave the market due to their adverse effects than their therapeutic effects. If the pharmacology of the drug and its adverse effect is Circadian Time (CT) dependent, it can be modulated by altering the time of administration of drugs. Chronopharmacology describes the effect of drugs in terms of time of administration. Its main objective is chronotherapy (time based treatment)...